Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• safely apply these nanomaterials for human healthcare, which strictly require assessment regarding quality control, safety, and efficacy. Many in vitro and in vivo assessments have been reported to prove the potential of metal-based nanomaterials for scavenging free radicals. FeO nanoparticles have 81

Nanomedicines against Chagas disease: a critical review

• Maria Jose Morilla,
• Kajal Ghosal and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 333–349, doi:10.3762/bjnano.15.30

• improve the bioavailability of the anti-hypercholesterolemic fenofibrate [88][89]. Polymeric nanoparticles and cell-derived vehicles such as exosomes have not entered the market yet because of issues regarding quality control, large-scale repeatable preparation, effectiveness, and safety [90]. The

• profile [113][114]. The industrial quality control is much more complex than that of conventional pharmaceuticals, focused mainly on the properties of the low-molecular-weight drug constituting the active pharmaceutical ingredient [115][116][117]. Given their structural complexity and high surface area

• risks [123]. The lack of universal regulatory protocols for good manufacturing practices of nanomedicines makes their quality control aspects overly complex [110][124]. In addition, the regulatory framework for a given nanomedicine will change according to the country, thereby hindering approval and

Comparative electron microscopy particle sizing of TiO₂ pigments: sample preparation and measurement

• Ralf Theissmann,
• Christopher Drury,
• Markus Rohe,
• Thomas Koch,
• Jochen Winkler and
• Petr Pikal

Beilstein J. Nanotechnol. 2024, 15, 317–332, doi:10.3762/bjnano.15.29

• developed over many years and are regularly used in each participating company for quality control and research purposes. The evaluated MinFeret and ECD values, with the exception of M3 for sample D, fall within the 95% confidence interval (Table 2). The observed standard deviation of the fraction of

In situ optical sub-wavelength thickness control of porous anodic aluminum oxide

• Aleksandrs Dutovs,
• Raimonds Popļausks,
• Oskars Putāns,
• Vladislavs Perkanuks,
• Aušrinė Jurkevičiūtė,
• Tomas Tamulevičius,
• Uldis Malinovskis,
• Iryna Olyshevets,
• Donats Erts and
• Juris Prikulis

Beilstein J. Nanotechnol. 2024, 15, 126–133, doi:10.3762/bjnano.15.12

• . This makes it particularly suitable for quality control in the small-scale production of thin PAAO membranes for optical applications and other uses, where precise thickness is of importance. Experimental A dedicated setup (Figure 5) was built and optimized for anodization of 10 mm × 10 mm aluminum

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• solution produced by reverse engineering, and make quality control more challenging [19]. Additionally, the degummed silk tends to aggregate when stored for long periods in an aqueous solution, typically for weeks at room temperature and for months at 4 °C [20]. Amongst various carriers, albumin seems to

Industrial perspectives for personalized microneedles

• Remmi Danae Baker-Sediako,
• Benjamin Richter,
• Matthias Blaicher,
• Michael Thiel and
• Martin Hermatschweiler

Beilstein J. Nanotechnol. 2023, 14, 857–864, doi:10.3762/bjnano.14.70

• ultimately impede quality control [49]. Finally, DLP- and SLA-fabricated microneedles are often dull with a low aspect ratio [50], and this again affects their performance (e.g., penetration). Hence, 3D printing via 2PP is currently the best commercially available microfabrication method to enable

On the use of Raman spectroscopy to characterize mass-produced graphene nanoplatelets

• Keith R. Paton,
• Konstantinos Despotelis,
• Naresh Kumar,
• Piers Turner and
• Andrew J. Pollard

Beilstein J. Nanotechnol. 2023, 14, 509–521, doi:10.3762/bjnano.14.42

• , although quantification of the amount remains approximate. We therefore recommend this approach as a robust methodology for reliable characterization of mass-produced graphene-related 2D materials using confocal Raman spectroscopy. Keywords: few-layer graphene; graphene; metrology; quality control; Raman

• applications for GR2Ms expands, and with it the production volumes, there is an increasing need for faster methods that can be applied in-line or at-line. These quality control methods do not need the same level of accuracy and precision as those specified in international standards, but they do need to be

• %), transmission electron microscopy (TEM) (7.2%) or X-ray photoelectron spectroscopy (XPS) (5.6%). It has the advantages of relatively low cost, simple sample preparation, quick measurements, and automated analysis, offering clear benefits for quality control applications. It has been demonstrated in several

Studies of probe tip materials by atomic force microscopy: a review

• Ke Xu and
• Yuzhe Liu

Beilstein J. Nanotechnol. 2022, 13, 1256–1267, doi:10.3762/bjnano.13.104

• detection line (T line) and a quality control line (C line) and causes the background fluorescence at that position to be burst, which is read by the instrument. The instrument read the background fluorescence value (T0) and the T-line fluorescence value (T1), and T0/T1 was calculated for the quantitative

Optimizing PMMA solutions to suppress contamination in the transfer of CVD graphene for batch production

• Chun-Da Liao,
• Andrea Capasso,
• Tiago Queirós,
• Telma Domingues,
• Fatima Cerqueira,
• Nicoleta Nicoara,
• Jérôme Borme,
• Paulo Freitas and
• Pedro Alpuim

Beilstein J. Nanotechnol. 2022, 13, 796–806, doi:10.3762/bjnano.13.70

• 4710-057, Portugal 10.3762/bjnano.13.70 Abstract Mass production and commercial adoption of graphene-based devices are held back by a few crucial technical challenges related to quality control. In the case of graphene produced by chemical vapor deposition, the transfer process represents a delicate

Bacterial safety study of the production process of hemoglobin-based oxygen carriers

• Axel Steffen,
• Yu Xiong,
• Radostina Georgieva,
• Ulrich Kalus and
• Hans Bäumler

Beilstein J. Nanotechnol. 2022, 13, 114–126, doi:10.3762/bjnano.13.8

• endotoxin content (and of course if all other quality control parameters are met) the produced batch of HbMP can be released for further use. These findings are an important part of our extensive safety concept. Experimental Materials Ringer's acetate solution was purchased from Serumwerk Bernburg AG

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• . Thenhipalam 673635, Kerala, India National Institute for Quality Control in Health, Oswaldo Cruz Foundation (INCQS, FIOCRUZ), Rio de Janeiro, RJ, Brazil 10.3762/bjnano.12.36 Abstract Recent studies with silver nanoparticles (AgNPs) and the history of silver metal as a broad-spectrum bactericidal and

• studies of this promising agent in nanomedicine and in clinical practice. Keywords: bactericidal agent; {111} facets; mechanism of action; silver ion; silver nanoparticles; quality control; virucidal agent; Review Introduction Silver is one of the oldest bactericidal agents in history and is also

• growth of AgNPs with various morphologies, such as nanocubes, nanowires, and nanospheres, as shown in Table 3 [139][140][142]. Minimum requirements for AgNP quality control The physical and chemical properties of nanoparticles are important for the study of their behavior, biodistribution, safety, and

BTEX detection with composites of ethylenevinyl acetate and nanostructured carbon

• Santa Stepina,
• Astrida Berzina,
• Gita Sakale and
• Maris Knite

Beilstein J. Nanotechnol. 2017, 8, 982–988, doi:10.3762/bjnano.8.100

• this study is to create a sensing material that could be used for BTEX sensing at room temperature and evaluate the EVA–CB capability in sensor applications in fuel quality control. In this study, a conductive structure of EVA–CB composites is characterised using AFM electroconductive measurements in

• detect gasoline and BTEX vapours and could be applied in future for fuel quality control. Schematic structure and dimensions of an EVA–CB sample. Reproduced with permission from [20], copyright 2011 Versita Warsaw and Springer-Verlag Wien. Expected relative change of the electrical resistance as a

Uptake of the proteins HTRA1 and HTRA2 by cells mediated by calcium phosphate nanoparticles

• Olga Rotan,
• Katharina N. Severin,
• Simon Pöpsel,
• Alexander Peetsch,
• Melisa Merdanovic,
• Michael Ehrmann and
• Matthias Epple

Beilstein J. Nanotechnol. 2017, 8, 381–393, doi:10.3762/bjnano.8.40

• organisms [29]. HtrAs are unique serine proteases. Besides their trypsin-like protease domain, they possess at least one C-terminal PDZ domain and can form higher oligomers [30]. The main functions of its family members are key aspects of the protein quality control process [29]. The best-studied members of

• , however, how its cellular distribution is regulated. HTRA2 is a human serine protease located in the intermembrane compartment of mitochondria [40]. It is known to be involved in mitochondrial quality control, namely through interactions with the antiapoptotic protein HAX-1 [41]. The degradation of this

• ]. Neurodegenerative disorders are strongly associated with the aggregation of proteins or protein fragments as well as the accumulation of unfolded proteins in mitochondria [36]. This implies that the HTRA2 protease plays a significant role in maintaining cellular homeostasis by means of protein quality control. The

False positives and false negatives measure less than 0.001% in labeling ssDNA with osmium tetroxide 2,2’-bipyridine

• Anastassia Kanavarioti

Beilstein J. Nanotechnol. 2016, 7, 1434–1446, doi:10.3762/bjnano.7.135

• where DNA does not absorb. This last feature enabled the development of a quality control UV–vis assay to confirm the extent of labeling [30][31][32]. It was hypothesized that a nanopore of suitable size would differentiate between osmylated and bare base due to their major differences in size and

Single pyrimidine discrimination during voltage-driven translocation of osmylated oligodeoxynucleotides via the α-hemolysin nanopore

• Yun Ding and
• Anastassia Kanavarioti

Beilstein J. Nanotechnol. 2016, 7, 91–101, doi:10.3762/bjnano.7.11

• protocols work at room temperature. The UV–vis assay serves as a quality control assay to confirm extent of osmylation. The realization that osmylation adds a 4-fold mass to the reacting base (Scheme 1, caption) fueled the speculation that any size-suitable nanopore could discriminate between osmylated and

• corresponding ratio following protocol B (see below). The values R1 and R2 serve as quality control of the product because they can be calculated from the relationships R1 = 2.21 × dT/Ntotal and R2 = 2.01 × (dT+dC)/Ntotal, where Ntotal is the total number of nucleotides, dT/Ntotal is the fraction of dT, and (dT

Nanocuration workflows: Establishing best practices for identifying, inputting, and sharing data to inform decisions on nanomaterials

• Christina M. Powers,
• Karmann A. Mills,
• Stephanie A. Morris,
• Fred Klaessig,
• Sharon Gaheen,
• Nastassja Lewinski and
• Christine Ogilvie Hendren

Beilstein J. Nanotechnol. 2015, 6, 1860–1871, doi:10.3762/bjnano.6.189

• associated repository. A focused effort on each step in the workflow facilitates the identification of critical elements within and between each step, such as information transfers from one individual to another, quality control checks, and access rights necessary to input or review data. When individuals in

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

• Marina E. Vance,
• Todd Kuiken,
• Eric P. Vejerano,
• Sean P. McGinnis,
• Michael F. Hochella Jr.,
• David Rejeski and
• Matthew S. Hull

Beilstein J. Nanotechnol. 2015, 6, 1769–1780, doi:10.3762/bjnano.6.181

• ) or suggest new products to the inventory. As a quality control measure, suggestions and new product forms contributed by registered users must be approved by a CPI curator before updates or revisions are posted to the inventory. Number of available products over time (since 2007) in each major

A scanning probe microscope for magnetoresistive cantilevers utilizing a nested scanner design for large-area scans

• Tobias Meier,
• Alexander Förste,
• Ali Tavassolizadeh,
• Karsten Rott,
• Dirk Meyners,
• Roland Gröger,
• Günter Reiss,
• Eckhard Quandt,
• Thomas Schimmel and
• Hendrik Hölscher

Beilstein J. Nanotechnol. 2015, 6, 451–461, doi:10.3762/bjnano.6.46

• sensing techniques as applications [2][3][4][5]. Current state of the art instruments use micro-fabricated silicon and silicon-nitride cantilevers with an optical read-out [6] and image with high resolution down to the atomic scale. Furthermore, AFMs are often incorporated into quality control systems for

• the small-area scanner enabling further zoom steps (Figure 3f). Thereby, the instrument can span over three orders of magnitude in scan range, which makes it a helpful tool for micro- and nanomechanical analysis. One example of such an analysis is given in Figure 4a. For quality control of fabrication

Interaction of dermatologically relevant nanoparticles with skin cells and skin

• Annika Vogt,
• Fiorenza Rancan,
• Sebastian Ahlberg,
• Berouz Nazemi,
• Chun Sik Choe,
• Maxim E. Darvin,
• Sabrina Hadam,
• Ulrike Blume-Peytavi,
• Kateryna Loza,
• Jörg Diendorf,
• Matthias Epple,
• Christina Graf,
• Eckart Rühl,
• Martina C. Meinke and
• Jürgen Lademann

Beilstein J. Nanotechnol. 2014, 5, 2363–2373, doi:10.3762/bjnano.5.245

• their ability to take up nanomaterial. The choice of the experimental system has a major influence on the generated information and a thorough quality control of the behavior of different particle batches in the experimental models is essential. Nanoparticle-induced biological effects in cells and whole

Functionalization of vertically aligned carbon nanotubes

• Eloise Van Hooijdonk,
• Carla Bittencourt,
• Rony Snyders and
• Jean-François Colomer

Beilstein J. Nanotechnol. 2013, 4, 129–152, doi:10.3762/bjnano.4.14

Large-scale analysis of high-speed atomic force microscopy data sets using adaptive image processing

• Blake W. Erickson,
• Séverine Coquoz,
• Jonathan D. Adams,
• Daniel J. Burns and
• Georg E. Fantner

Beilstein J. Nanotechnol. 2012, 3, 747–758, doi:10.3762/bjnano.3.84

• [30][31]. Automated, AFM quality-control check in semiconductors and other nanotechnologies [32][33][34] also creates large data sets, which would also benefit from reliable automated image processing. In order to automate the image processing, it is important to define a metric by which the success

Glassy carbon electrodes modified with multiwalled carbon nanotubes for the determination of ascorbic acid by square-wave voltammetry

• Sushil Kumar and
• Victoria Vicente-Beckett

Beilstein J. Nanotechnol. 2012, 3, 388–396, doi:10.3762/bjnano.3.45

• during the production and quality-control stages and in clinical applications [3][4][5]. Several methods for the determination of ascorbic acid concentration have been reported, such as HPLC [6], enzymatic analysis [7] and spectrophotometry [7]. However, these methods are relatively time-consuming and/or

Preparation, properties and applications of magnetic nanoparticles

• Ulf Wiedwald and
• Paul Ziemann

Beilstein J. Nanotechnol. 2010, 1, 21–23, doi:10.3762/bjnano.1.4

• arrays of the NPs, in the ideal case two-dimensionally periodic arrangements. To this end, highly reliable and reproducible self-organizing processes are sought allowing a high throughput at a tolerable price. Preparation, however, has to be accompanied by a strict quality control including the particles